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Faulty cellular antennae may cause a heart valve disorder


Added 05-22-19 02:16:02pm EST - “Mitral valve prolapse might be caused by dysfunctional primary cilia meant to signal cells during development.” - Sciencenews.org

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Posted By TheNewsCommenter: From Sciencenews.org: “Faulty cellular antennae may cause a heart valve disorder”. Below is an excerpt from the article.

In the May 11 & 25 SN: High-tech cricket farming, AI learns from Minecraft, looking for lithium, a new hominid species is named, signs of life in dead pig brains, Cherokee cave texts decoded, water molecules on the moon and more. 

HEART MURMUR  Mitral valve prolapse — a leaky valve between two chambers of the heart — can produce a “click” sound that is detectable with a stethoscope.

Cells with faulty antennae that can’t get their signals straight may be behind a common heart valve disorder.

Newborn mice engineered to develop a flawed heart valve had stunted primary cilia in cells that help to form the valve during development, researchers report online May 22 in Science Translational Medicine.

The heart valve disorder, called mitral valve prolapse, “is characterized by significant abnormalities in the composition and organization” of valve tissue, says Joy Lincoln, a heart valve researcher at Nationwide Children’s Hospital in Columbus, Ohio. Those abnormalities compromise the valve’s structure and function. The new work hints that primary cilia play a role in this improper development, she says.

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